Iodine-Promoted Synthesis of Thioamides from 1,2-Dibenzyl­sulfane and Difurfuryl Disulfide

Sihai Chen, You Li, Jinyang Chen, Xinhua Xu*, Lebin Su, Zhi Tang, Chak-Tong Au, Renhua Qiu*

*State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. of China, Email: xhx1581hnu.edu.cn, renhuaqiuhnu.edu.cn

S. Chen, Y. Li, J. Chen, X. Xu, L. Su, Z. Tang, C.-T. Au, R. Qiu, Synlett, 2016, 27, 2339-2344.

DOI: 10.1055/s-0035-1562509

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Abstract

A metal- and additive-free reaction of 1,2-dibenzyldisulfanes with amines using iodine as oxidant and DMSO as solvent at 100°C provides various thioamides in high yields.

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Key Words

thioamides, metal-free, iodine, disulfides, DMSO

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ID: J60-Y2016