Borane-Catalyzed Transfer Hydrogenations of Pyridines with Ammonia Borane
Qiwen Zhou, Lanqiong Zhang, Wei Meng, Xiangqing Feng, Jing Yang* and Haifeng Du*
*College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029; Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Email: yangjmail.buct.edu.cn, haifengduiccas.ac.cn
Q. Zhou, L. Zhang, W. Meng, X. Feng, J. Yang, H. Du, Org. Lett., 2016, 18, 5189-5191.
DOI: 10.1021/acs.orglett.6b02610 (free Supporting Information)
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A borane catalyzed metal-free transfer hydrogenation of pyridines furnishes various piperidines in good yields with good cis-selectivities in the presence of ammonia borane as a hydrogen source. The ease in handling without requiring high pressure H2 makes this transfer hydrogenation practical and useful.
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