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Borane-Catalyzed Transfer Hydrogenations of Pyridines with Ammonia Borane

Qiwen Zhou, Lanqiong Zhang, Wei Meng, Xiangqing Feng, Jing Yang* and Haifeng Du*

*College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029; Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Email: yangjmail.buct.edu.cn, haifengduiccas.ac.cn

Q. Zhou, L. Zhang, W. Meng, X. Feng, J. Yang, H. Du, Org. Lett., 2016, 18, 5189-5191.

DOI: 10.1021/acs.orglett.6b02610 (free Supporting Information)


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A borane catalyzed metal-free transfer hydrogenation of pyridines furnishes various piperidines in good yields with good cis-selectivities in the presence of ammonia borane as a hydrogen source. The ease in handling without requiring high pressure H2 makes this transfer hydrogenation practical and useful.

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Key Words

piperidines, borane


ID: J54-Y2016