Organic Chemistry Portal

Abstracts

Search:

Hydrogen Peroxide Promoted Metal-Free Oxidation/Cyclization of α-Hydroxy N-Arylamides: A Facile One-Pot Synthesis of Isatins

Jie Li, Xu Cheng, Xiaojun Ma, Guanghui Lv, Zhen Zhan, Mei Guan*, Yong Wu*

*West China Hospital and West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. of China, Email: wyongscu.edu.cn, meiguan92163.com

J. Li, X. Cheng, X. Ma, G. Lv, Z. Zhan, M. Guan, Y. Wu, Synlett, 2016, 27, 2485-2488.

DOI: 10.1055/s-0035-1562517 (free Supporting Information)


Abstract

An efficient and environmentally friendly conversion of α-hydroxy N-arylamides into isatins in very good yields proceeded smoothly under metal-free conditions in the presence of hydrogen peroxide as oxidant. This convenient method offers broad substrate scope.


see article for more examples



Key Words

hydrogen peroxide, hydroxy amides, isatins, cyclization, indoles


ID: J60-Y2016