Palladium-Catalyzed Regio- and Enantioselective Synthesis of Allylic Amines Featuring Tetrasubstituted Tertiary Carbons
Aijie Cai, Wusheng Guo*, Luis Martínez-Rodríguez and Arjan W. Kleij*
*Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Paďsos Catalans 16, 43007 Tarragona, Spain, Email: wguoiciq.es, akleijiciq.es
A. Cai, W. Guo, L. Martínez-Rodríguez, A. W. Kleij, J. Am. Chem. Soc., 2016, 138, 14194-14197.
DOI: 10.1021/jacs.6b08841
see article for more reactions
Abstract
A palladium-catalyzed allylic amination enables an asymmetric synthesis of α,α-disubstituted allylic N-arylamines from highly modular vinyl cyclic carbonates and unactivated aromatic amine nucleophiles. The catalytic process features minimal waste production, high asymmetric induction, and operational simplicity.
see article for more examples
Key Words
allylic amines, arylamines, β-amino alcohols
ID: J48-Y2016