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Bidentate Directing-Enabled, Traceless Heterocycle Synthesis: Cobalt-Catalyzed Access to Isoquinolines

Shuguang Zhou, Mingyang Wang, Lili Wang, Kehao Chen, Jinhu Wang, Chao Song and Jin Zhu*

*Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University, Nanjing 210093, China, Email: jinznju.edu.cn

S. Zhou, M. Wang, L. Wang, K. Chen, J. Wang, C. Song, J. Zhu, Org. Lett., 2016, 18, 5632-5635.

DOI: 10.1021/acs.orglett.6b02870


Abstract

A bidentate 2-hydrazinylpyridine directing system enables a high catalytic reactivity without the need for a high-cost privileged ligand in a cobalt-catalyzed synthesis of isoquinolines via C-H coupling/cyclization with alkynes.

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Key Words

isoquinolines, oxygen


ID: J54-Y2016