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An Effective Pd-Catalyzed Regioselective Hydroformylation of Olefins with Formic Acid

Wenlong Ren, Wenju Chang, Jie Dai, Yuan Shi, Jingfu Li and Yian Shi*

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States, Email:

W. Ren, W. Chang, J. Dai, Y. Shi, J. Li, Y. Shi, J. Am. Chem. Soc., 2016, 138, 14864-14867.

DOI: 10.1021/jacs.6b10297 (free Supporting Information)


An effective and operationally simple palladium-catalyzed regioselective hydroformylation of olefins with formic acid provides linear aldehydes in good yield with excellent regioselectivity. 1,3-Bis(diphenylphosphino)propane (dppp) as the ligand plays a crucial role in directing the reaction pathway. The process requires no syngas.

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A Ligand-Directed Catalytic Regioselective Hydrocarboxylation of Aryl Olefins with Pd and Formic Acid

W. Liu, W. Ren, J. Li, Y. Shi, W. Chang, Y. Shi, Org. Lett., 2017, 19, 1748-1751.

Palladium-Catalyzed Highly Regio- and Enantioselective Hydroesterification of Aryl Olefins with Phenyl Formate

J. Li, W. Chang, W. Ren, J. Dai, Y. Shi, Org. Lett., 2016, 18, 5456-5459.

Facile Palladium-Catalyzed Hydrocarboxylation of Olefins without External CO Gas

Y. Wang, W. Ren, J. Li, H. Wang, Y. Shi, Org. Lett., 2014, 16, 5960-5963.

Key Words

carbonyl compounds

ID: J48-Y2016