Enantioselective Rhodium-Catalyzed Allylic Alkylation of Prochiral α,α-Disubstituted Aldehyde Enolates for the Construction of Acyclic Quaternary Stereogenic Centers
Timothy B. Wright and P. Andrew Evans*
*Department of Chemistry Queen's University, 90 Bader Lane,
Kingston, Ontario K7L 3N6, Canada, Email: Andrew.Evans
chem.queensu.ca
T. B. Wright, P. A. Evans, J. Am. Chem. Soc., 2016, 138, 15303-15306.
DOI: 10.1021/jacs.6b10099
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Abstract
A highly enantioselective rhodium-catalyzed allylic alkylation of prochiral α,α-disubstituted aldehyde enolates with allyl benzoate provides acyclic quaternary carbon stereogenic centers.
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Key Words
ID: J48-Y2016
