Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas
Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto* and Takashi Ohshima*
*Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, Email: hmorimotphar.kyushu-u.ac.jp, ohshimaphar.kyushu-u.ac.jp
M. Noshita, Y. Shimizu, H. Morimoto, T. Ohshima, Org. Lett., 2016, 18, 6062-6065.
DOI: 10.1021/acs.orglett.6b03016 (free Supporting Information)
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Diethylenetriamine is effective for a chemoselective direct cleavage of unactivated carbamates and ureas without additional reagents and catalysts. The method affords products in good yield and is not affected by air or moisture.
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