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Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas

Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto* and Takashi Ohshima*

*Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, Email: hmorimotphar.kyushu-u.ac.jp, ohshimaphar.kyushu-u.ac.jp

M. Noshita, Y. Shimizu, H. Morimoto, T. Ohshima, Org. Lett., 2016, 18, 6062-6065.

DOI: 10.1021/acs.orglett.6b03016 (free Supporting Information)


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Abstract

Diethylenetriamine is effective for a chemoselective direct cleavage of unactivated carbamates and ureas without additional reagents and catalysts. The method affords products in good yield and is not affected by air or moisture.


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Key Words

cleavage of carbamates


ID: J54-Y2016