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Copper-Catalyzed Direct Coupling of Unprotected Propargylic Alcohols with P(O)H Compounds: Access to Allenylphosphoryl Compounds under Ligand- and Base-Free Conditions

Gaobo Hu, Changkai Shan, Weizhu Chen, Pengxiang Xu, Yuxing Gao* and Yufen Zhao

*Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China, Email: gaoxingchemxmu.edu.cn

G. Hu, C. Shan, W. Chen, P. Xu, Y. Gao, Y. Zhao, Org. Lett., 2016, 18, 6066-6069.

DOI: 10.1021/acs.orglett.6b03028 (free Supporting Information)


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Abstract

A facile and efficient copper-catalyzed direct C-P cross-coupling of unprotected propargylic alcohols with P(O)H compounds provides valuable allenylphosphoryl frameworks with operational simplicity and high step- and atom-economy under ligand-, base-, and additive-free conditions.

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Key Words

phosphine oxides, allenes


ID: J54-Y2016