E- and Z-Selective Transfer Semihydrogenation of Alkynes Catalyzed by Standard Ruthenium Olefin Metathesis Catalysts
Rafał Kusy and Karol Grela*
*Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, P.O. Box 58, 01-224 Warsaw, Poland, Email: karol.grelagmail.com
R. Kusy, K. Grela, Org. Lett., 2016, 18, 6196-6199.
DOI: 10.1021/acs.orglett.6b03254 (free Supporting Information)
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Commercial first and second generation Hoveyda-Grubbs catalysts enable a selective transfer semihydrogenation of alkynes to yield alkenes in the presence of formic acid as a hydrogen donor. This catalytic system tolerates many functional groups (halogens, cyano, nitro, sulfide, alkenes).
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