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Copper-Catalyzed Tandem Reaction of 2-Aminobenzamides with Tertiary Amines for the Synthesis of Quinazolinone Derivatives

Wei Xu, Xiao-Rui Zhu, Peng-Cheng Qian, Xing-Guo Zhang, Chen-Liang Deng*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China, Email: dcl78wzu.edu.cn

W. Xu, X.-R. Zhu, P.-C. Qian, X.-G. Zhang, C.-L. Deng, Synlett, 2016, 27, 2851-2857.

DOI: 10.1055/s-0036-1588881 (free Supporting Information)


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Abstract

A copper-catalyzed tandem reaction of 2-aminobenzamides with tertiary amines provides quinazolinone derivatives. A broad range of substrates reacted under the standard conditions to give the corresponding quinazolinone derivatives in good yields.

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proposed reaction pathway



Key Words

copper catalysis, tandem reactions, aminobenzamides, tertiary amines, quinazolinones, oxygen, DDQ


ID: J60-Y2016