Palladium-Catalyzed Cyclization-Heck Reaction of Allenamides: An Approach to 3-Methylene-5-phenyl-1,2,3,4-tetrahydropyridine Derivatives
Fachao Yan, Hanbing Liang, Jian Song, Jie Cui, Qing Liu, Sheng Liu, Ping Wang, Yunhui Dong* and Hui Liu*
*School of Chemical Engineering, Shandong University of
Technology, 266 West Xincun Road, Zibo 255049, P. R. China, Email: dyh651118
126.com,
huiliu1030sdut.edu.cn
F. Yan, H. Liang, J. Song, J. Cui, Q. Liu, S. Liu, P. Wang, Y. Dong, H. Liu, Org. Lett., 2017, 19, 86-89.
DOI: 10.1021/acs.orglett.6b03364
see article for more reactions
Abstract
A palladium-catalyzed cyclization-Heck reaction of allenamides enables an efficient one-pot construction of functionalized 3-methylene-5-aryl-1,2,3,4-tetrahydropyridines. These compounds feature a nonconjugated diene, including one endo-enamine and one exocyclic double bond, which could be used for further transformation.
see article for more examples
proposed mechanism
Key Words
ID: J54-Y2017
