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Synthesis of Quinolines through Three-Component Cascade Annulation of Aryl Diazonium Salts, Nitriles, and Alkynes

Hao Wang, Qian Xu, Sheng Shen* and Shouyun Yu*

*School of Medicine, Nanjing University, Nanjing 210008; School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China, Email: txdqxdl1979163.com, yushouyunnju.edu.cn

H. Wang, Q. Xu, S. Shen, S. Yu, J. Org. Chem., 2017, 82, 770-775.

DOI: 10.1021/acs.joc.6b02509 (free Supporting Information)



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Abstract

A three-component cascade annulation of readily available aryl diazonium salts, nitriles, and alkynes enables an efficient, additive-free, and rapid synthesis of multiply substituted quinolines in good yields. Various aryl diazonium salts, nitriles, and alkynes can participate in this transformation.


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proposed mechanism



Key Words

quinolines, multicomponent reactions


ID: J42-Y2017