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Pyridine-Catalyzed Radical Borylation of Aryl Halides

Li Zhang and Lei Jiao*

*Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 10084, China, Email: Leijiaomail.tsinghua.edu.cn

L. Zhang, L. Jiao, J. Am. Chem. Soc., 2017, 139, 607-610.

DOI: 10.1021/jacs.6b11813 (free Supporting Information)


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Abstract

A selective cross-coupling of an aryl radical and a pyridine-stabilized boryl radical enables a transition-metal-free borylation reaction of haloarenes under mild conditions. This pyridine-catalyzed borylation features a broad substrate scope, operational simplicity, and gram-scale synthetic ability.

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proposed mechanism



Key Words

borylation


ID: J48-Y2017