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Palladium-Catalyzed Suzuki-Miyaura Coupling of Aryl Esters

Taoufik Ben Halima, Wanying Zhang, Imane Yalaoui, Xin Hong, Yun-Fang Yang, Kendall N. Houk* and Stephen G. Newman*

*University of California, Los Angeles, California 90095, United States; University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada, Email: houkchem.ucla.edu, stephen.newmanuottawa.ca

T. B. Halima, W. Zhang, I. Yalaoui, X. Hong, Y.-F. Yang, K. N. Houk, S. G. Newman, J. Am. Chem. Soc., 2017, 139, 1311-1318.

DOI: 10.1021/jacs.6b12329 (free Supporting Information)



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Abstract

An NHC-based Pd catalyst enables a Suzuki-Miyaura coupling of aryl esters as electrophiles to provide various ketone-containing products. This contrasts known reactions of similar esters that provide biaryls via nickel catalysis.

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Key Words

Suzuki coupling, aryl ketones


ID: J48-Y2017