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Free-Radical Bromotrifluoromethylation of Olefin via Single-Electron Oxidation of NaSO2CF3 by NaBrO3

Zhong-Quan Liu* and Dong Liu

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, P. R. China, Email: liuzhqlzu.edu.cn

Z.-Q. Liu, D. Liu, J. Org. Chem., 2017, 82, 1649-1656.

DOI: 10.1021/acs.joc.6b02812 (free Supporting Information)


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Abstract

The use of NaSO2CF3 and NaBrO3 enables a free-radical bromotrifluoromethylation of olefins via a radical process. Sodium bromate acts not only as a single-electron oxidant but also as a bromine source.

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proposed mechanism



Key Words

trifluoromethylation, bromination, sodium bromate


ID: J42-Y2017