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Isoindolinones via Copper-Catalyzed Intramolecular Benzylic C-H Sulfamidation

Robin B. Bedford* , John G. Bowen and Carolina Méndez-Gálvez

*School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K., Email: r.bedfordbristol.ac.uk

R. B. Bedford, J. G. Bowen, C. Méndez-Gálvez, J. Org. Chem., 2017, 82, 1719-1725.

DOI: 10.1021/acs.joc.6b02970 (free Supporting Information)


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Abstract

2-Benzyl-N-tosylbenzamides and related substrates undergo copper-catalyzed intramolecular benzylic sulfamidation to provide N-arylsuflonyl-1-arylisoindolinones.

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Key Words

Isoindolinones, PIDA


ID: J42-Y2017