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N,N-Dimethylformamide (DMF) as a Source of Oxygen To Access α-Hydroxy Arones via the α-Hydroxylation of Arones

Weibing Liu* , Cui Chen and Peng Zhou

*College of Chemical Engineering, Guangdong University of Petrochemical Technology, 2 Guandu Road, Maoming 525000, P. R. China, Email: lwb409gdupt.edu.cn

W. Liu, C. Chen, P. Zhou, J. Org. Chem., 2017, 82, 2219-2222.

DOI: 10.1021/acs.joc.6b02751 (free Supporting Information)


Abstract

An unprecedented α-hydroxylation strategy using inexpensive N,N-dimethylformamide (DMF) as an oxygen source enables the synthesis of α-hydroxy arones. This reaction provides an alternative strategy for the α-hydroxylation of arones.

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proposed mechanism



Key Words

α-hydroxylation, iodine


ID: J42-Y2017