Merging Photoredox with Copper Catalysis: Decarboxylative Alkynylation of α-Amino Acid Derivatives
Hao Zhang, Pengxiang Zhang, Min Jiang, Haijun Yang and Hua Fu*
*Key Laboratory of Bioorganic Phosphorus Chemistry and
Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua
University, Beijing 100084, China,
Email: fuhua
mail.tsinghua.edu.cn
H. Zhang, P. Zhang, M. Jiang, H. Yang, H. Fu, Org. Lett., 2017, 19, 1016-1019.
DOI: 10.1021/acs.orglett.6b03888
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Abstract
Merging photoredox with copper catalysis enables an efficient decarboxylative alkynylation of N-(acetoxy)phthalimides of α-amino acids with terminal alkynes at room temperature to provide valuable propargylamines in very good yields. This [Ru(bpy)3]Cl2/CuI catalyzed simple protocol offers mild reaction conditions and high efficiency.
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Key Words
ID: J54-Y2017
