Nickel-Catalyzed Synthesis of Quinazolinediones
Gregory L. Beutner* , Yi Hsiao, Thomas Razler, Eric M. Simmons and William Wertjes
*Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States, Email: gregory.beutnerbms.com
G. L. Beutner, Y. Hsiao, T. Razler, E. M. Simmons, W. Wertjes, Org. Lett., 2017, 19, 1052-1055.
DOI: 10.1021/acs.orglett.7b00052
see article for more reactions
Abstract
XANTPHOS has been identified as the optimal ligand for a nickel(0)-catalyzed synthesis of quinazolinediones from isatoic anhydrides and isocyanates. Preliminary results on an asymmetric synthesis of atropisomeric quinazolinediones are reported too.
see article for more examples
Key Words
ID: J54-Y2017