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Cobalt-Catalyzed α-Alkylation of Ketones with Primary Alcohols

Guoqi Zhang*, Jing Wu, Haisu Zeng, Shu Zhang, Zhiwei Yin and Shengping Zheng

*Department of Sciences, John Jay College and Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10019, United States, Email: guzhangjjay.cuny.edu

G. Zhang, J. Wu, H. Zeng, S. Zhang, Z. Yin, S. Zheng, Org. Lett., 2017, 19, 1080-1083.

DOI: 10.1021/acs.orglett.7b00106 (free Supporting Information)


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Abstract

An ionic cobalt-PNP complex enables an efficient α-alkylation of ketones with primary alcohols. A broad range of ketone and alcohol substrates provides alkylated ketones in good yields. The method was also successfully applied to a greener synthesis of quinoline derivatives using 2-aminobenzyl alcohol as the alkylating reagent.

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Key Words

carbonyl compounds, benzylation


ID: J54-Y2017