CBr4 as a Halogen Bond Donor Catalyst for the Selective Activation of Benzaldehydes to Synthesize α,β-Unsaturated Ketones
Imran Kazi, Somraj Guha and Govindasamy Sekar*
*Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600036, India, Email: gsekariitm.ac.in
I. Kazi, S. Guha, G. Sekar, Org. Lett., 2017, 19, 1244-1247.
DOI: 10.1021/acs.orglett.7b00348
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Abstract
CBr4 as a halogen bond donor catalyst enables a selective activation of aldehydes, to achieve an efficient solvent- and metal-free C═C bond forming reaction in the presence of strong acid sensitive groups such as methoxy, cyanide, ester, and ketal for the synthesis of α,β-unsaturated ketones.
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Plausible Reaction Mechanism for the α,β-Unsaturated Ketones Synthesis
Key Words
ID: J54-Y2017