Formal Allylic C(sp³)-H Bond Activation of Alkenes Triggered by a Sodium Amide

Wei Bao, Hanno Kossen and Uwe Schneider*

*EaStCHEM School of Chemistry, The University of Edinburgh, The King's Buildings, David Brewster Road, Edinburgh EH9 3FJ, U.K., Email: uwe.schneidered.ac.uk

W. Bao, H. Kossen, U. Schneider, J. Am. Chem. Soc., 2017, 139, 4362-4365.

DOI: 10.1021/jacs.7b01542

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Abstract

The catalytic use of a sodium amide enables a formal allylic C(sp³)-H bond activation of alkenes under mild conditions. Subsequent C-C bond formations with imines have proceeded in high yields with complete regioselectivity and excellent geometric selectivity.

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Key Words

homoallylic amines

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ID: J48-Y2017