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Silver-Catalyzed Decarboxylative Bromination of Aliphatic Carboxylic Acids

Xinqiang Tan, Tao Song, Zhentao Wang, He Chen, Lei Cui and Chaozhong Li*

*Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email: cligmail.sioc.ac.cn

X. Tan, T. Song, Z. Wang, H. Chen, L. Cui, C. Li, Org. Lett., 2017, 19, 1634-1637.

DOI: 10.1021/acs.orglett.7b00439 (free Supporting Information)


Abstract

A catalytic Hunsdiecker bromination of aliphatic carboxylic acids with Ag(Phen)2OTf as the catalyst and dibromoisocyanuric acid as the brominating agent provides alkyl bromides under mild conditions. This method not only is efficient and general but also tolerates a wide range of functional groups.

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Silver-Catalyzed Decarboxylative Chlorination of Aliphatic Carboxylic Acids

Z. Wang, L. Zhu, F. Yin, Z. Su, Z. Li, C. Li, J. Am. Chem. Soc., 2012, 134, 4258-4263.


Key Words

Hunsdiecker Reaction, Alkyl Bromides, Benzyl Bromides, Dibromoisocyanuric Acid


ID: J54-Y2017