A Novel PPh₃ Mediated One-Pot Method for Synthesis of 3-Aryl or Alkyl 1,2-Benzisoxazoles

GuiFang Chen, Hong Liu , ShuJia Li, Yu Tang*, PeiYao Lu, KaiTian Xu and YuanMing Zhang*

*Department of Chemistry, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China, Email: tytangjnu.edu.cn, tzhangymjnu.edu.cn

G. Chen, H. Liu, S. Li, Y. Tang, P. Lu, K. Xu, Y. Zhang, Org. Lett., 2017, 19, 1792-1795.

DOI: 10.1021/acs.orglett.7b00563

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Abstract

An efficient and facile PPh₃-mediated Barbier-Grignard-type reaction provides various 3-aryl or alkyl substituted 1,2-benzisoxazoles from 2-hydroxybenzonitriles and bromides in good yields.

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Key Words

1,2-benzisoxazoles

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ID: J54-Y2017