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X-ray Absorption and Electron Paramagnetic Resonance Guided Discovery of the Cu-Catalyzed Synthesis of Multiaryl-Substituted Furans from Aryl Styrene and Ketones Using DMSO as the Oxidant

Yong Wu, Zhiyuan Huang, Yi Luo, Dong Liu, Yi Deng, Hong Yi, Jyh-Fu Lee, Chih-Wen Pao, Jeng-Lung Chen and Aiwen Lei*

*College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei 430072, P.R. China, Email:

Y. Wu, Z. Huang, Y. Luo, D. Liu, Y. Deng, H. Yi, J.-Fu. Lee, C.-W. Pao, J.-L. Chen, A. Lei, Org. Lett., 2017, 19, 2330-2333.

DOI: 10.1021/acs.orglett.7b00865 (free Supporting Information)

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A copper-catalyzed oxidative cyclization of aryl ketones with styrenes to furans, in which DMSO serves not only as a solvent but also as an oxidant, provides multiaryl-substituted furans from cheap and readily available starting materials.

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Key Words

furans, DMSO

ID: J54-Y2017