Synthesis of Functionalized Pyrazolo[1,5-a]pyridines: [3+2] Cycloaddition of N-Aminopyridines and α,β-Unsaturated Carbonyl Compounds/Alkenes at Room Temperature
Chitrakar Ravi, Supravat Samanta, Darapaneni Chandra Mohan, N. Naresh Kumar Reddy, Subbarayappa Adimurthy*
*Central Salt & Marine Chemicals Research Institute, Council
of Scientific & Industrial Research, G.B. Marg, Bhavnagar-364 002, Gujarat,
India, Email:
adimurthy
csmcri.org
C. Ravi, S. Samanta, D. C. Mohan, N. N. K. Reddy, S. Adimurthy, Synthesis, 2017, 49, 2513-2522.
DOI: 10.1055/s-0036-1588753
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Abstract
The synthesis of functionalized pyrazolo[1,5-a]pyridines through oxidative [3+2] cycloaddition of N-aminopyridines with α,β-unsaturated carbonyl compounds or electron-withdrawing olefins proceeds in N-methylpyrrolidone as the solvent under metal-free conditions at room temperature.
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Key Words
N-methylpyrrolidone, chalcones, pyrazolo[1,5-a]pyridines, metal-free, drug intermediates, [3+2] cycloaddition, oxygen
ID: J66-Y2017
