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Group 5 and group 6 metal halides as very efficient catalysts for acylative cleavage of ethers

Qiaoxia Guo, Taichi Miyaji, Ryuichiro Hara, Baojian Shen and Tamotsu Takahashi*

*Catalysis Research Center and Graduate School of Pharmaceutical Sciences, Hokkaido University and CREST, Japan Science and Technology Corporation (JST), Sapporo 060-0811, Japan, Email: tamotsucat.hokudai.ac.jp

Q. Guo, T. Miyaji, R. Hara, B. Shen, T. Takahashi, Tetrahedron, 2002, 58, 7327-7334.

DOI: 10.1016/S0040-4020(02)00738-X


Abstract

Group 5 and 6 metal chlorides were found as very efficient catalysts for acylative cleavage of ethers. Compared with conventional Lewis acid catalysts, group 5 and 6 metal chlorides showed better results in the catalytic C-O bond cleavage.

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proposed mechanism



Key Words

Lewis Acids, Ether, Ester, Alkyl Chloride


ID: J72-Y2002-170