Poly(ethylene glycol) (PEG) as a Reusable Solvent Medium for Organic Synthesis. Application in the Heck Reaction
S. Chandrasekhar*, Ch. Narsihmulu, S. Shameem Sultana and N. Ramakrishna Reddy
*Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email: srivariciict.ap.nic.in
S. Chandrasekhar, C. Narsihmulu, S. S. Sultana, N. R. Reddy, Org. Lett., 2002, 4, 4399-4401.
DOI: 10.1021/ol0266976 (free Supporting Information)
Low molecular PEG has been used as a solvent for a ligand-free Heck reaction with easy recyclability of solvent and Pd catalyst. The reaction works well for electron-deficient and electron-rich olefins with high regio- and stereoselectivities.
see article for more reactions