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Highly Enantioselective 1,4-Addition of Diorganozinc Reagents to Cyclic Enones Using Chiral Diphosphite Ligands Derived from H8-Binaphtol

Liang Liang, Terry T.-L. Au-Yeung and Albert S. C. Chan*

*The Hong Kong Polytechnic University, Hong Kong, China, Email: bcachanpolyu.edu.hk

L. Liang, T. T.-L. Au-Yeung, A. S. C. Chan, Org. Lett., 2002, 4, 3799-3801.

DOI: 10.1021/ol026581+


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Abstract

The 1,4-addition of dialkylzincs to cyclic enones proceeded with ee values up to 99% by using chiral aryl diphosphite ligands derived from H8-binaphthol.

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Key Words

conjugate addition


ID: J54-Y2002-290