Palladium-Promoted Arylation of Functionalised Organolithium Compounds via Their Zinc Derivatives
Miguel Yus* and Joaquín Gomis
*Departamento de Quimica Orgánica, Facultad de Ciencias,
Universidad de Alicante, Apdo. 99, E-03080 Alicante, Spain, Email: yus
ua.es
M. Yus, J. Gomis, Eur. J. Org. Chem., 2002, 1989-1995.
DOI: 10.1002/1099-0690(200206)2002:12<1989::AID-EJOC1989>3.0.CO;2-A
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Abstract
The reaction of different functionalised organolithium compounds prepared by DTBB-catalysed lithiation of isochromane, phthalane, 2,3-dihydrobenzofuran and 1-chloro-3,3-diethoxypropane with an equimolecular amount of zinc bromide, followed by reaction with an aryl or an alkenyl bromide in the presence of a palladium catalyst gives the expected cross-coupling products.
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Key Words
Lithium, Zinc, Palladium, Cross-Coupling, Lithiation, Negishi-Coupling, Diarylmethanes
ID: J24-Y2002-320
