Carbon Monoxide Free Aminocarbonylation of Aryl and Alkenyl Iodides Using DMF as an Amide Source

Kazushi Hosoi, Kyoko Nozaki* and Tamejiro Hiyama

*Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan, Email: nozakichembio.t.u-tokyo.ac.jp

K. Hosoi, K. Nozaki, T. Hiyama, Org. Lett., 2002, 4, 2849-2851.

DOI: 10.1021/ol026236k (free Supporting Information)

Abstract

Tertiary amides can be synthesized by a palladium-catalyzed coupling of N,N-dimethylformamide with aryl or alkenyl halides in the presence of phosphoryl chloride.

proposed mechanism

Key Words

Benzamides, Aminocarbonylation

ID: J54-Y2002-360