A Copper-Catalyzed C-N Bond Formation Involving sp-Hybridized Carbons. A Direct Entry to Chiral Ynamides via N-Alkynylation of Amides
Michael O. Frederick, Jason A. Mulder, Michael R. Tracey, Richard P. Hsung,* Jian Huang, Kimberly C. M. Kurtz, Lichun Shen and Christopher J. Douglas
*Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, Email: rphsungpharmacy.wisc.edu
M. O. Frederick, J. A. Mulder, M. R. Tracey, R. P. Hsung, J. Huang, K. C. M. Kurtz, L. Shen, C. J. Douglas, J. Am. Chem. Soc., 2003, 125, 2368-2369.
DOI: 10.1021/ja021304j
Abstract
A copper-catalyzed direct N-alkynylation of amides has been developed leading to a facile entry for syntheses of chiral ynamides.
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X. Zhang, Y. Zhang, J. Huang, R. P. Hsung, K. C. M. Kurtz, J. Oppenheimer, M. E. Petersen, I. K. Sagamanova, L. Shen, M. R. Tracey, J. Org. Chem., 2006, 71, 4170-4177.
Key Words
ID: J48-Y2003-1320