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A General Method for the Formation of Aryl-Sulfur Bonds Using Copper(I) Catalysts

Craig G. Bates, Rattan K. Gujadhur, D. Venkataraman*

*Department of Chemistry, University of Massachusetts, 710 N. Pleasant Street, Amherst, Massachusetts 01003, Email: dvchem.umass.edu

C. G. Bates, R. K. Gujadhur, D. Venkataraman, Org. Lett., 2002, 4, 2803-2806.

DOI: 10.1021/ol0264105 (free Supporting Information)


Abstract

A mild, palladium-free method for C-S-bond formation is reported. The standard protocol using 10 mol-% CuI, 10 mol-% neocuproine, with NaOtBu as the base gave aryl sulfides in excellent yields from thiols and iodides.



Key Words

Cross-coupling, Aryl Iodides, Thiols, CuI, Neocuproine, Aryl Sulfides, Ullmann Reaction


ID: J54-Y2002-470