Organic Chemistry Portal

Abstracts

Search:

Synthesis of Arylglycines by Reaction of Diethyl N-Boc-iminomalonate with Organomagnesium Reagents

Patrizia Calí, Mikael Begtrup*

*Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Universitetsparken 2, 2100 Copenhagen, Denmark, Email: mbdfuni.dk

P. Cali, M. Begtrup, Synthesis, 2002, 63-64.

DOI: 10.1055/s-2002-19301


see article for more examples

Abstract

Diethyl N-Boc-iminomalonate, prepared on multi-gram scale, served as a stable and highly reactive electrophilic glycine equivalent which reacted with organomagnesium compounds affording substituted aryl N-Boc-aminomalonates. Subsequent hydrolysis produced arylglycines.

   see article for more reactions



Key Words

amino acids, arylaminomalonates, arylglycines, imino esters, Grignard reaction, tert-butyl carbamates, decarboxylation


ID: J66-Y2002-1430