Catalysis of the Biginelli Reaction by Ferric and Nickel Chloride Hexahydrates. One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones
Jun Lu*, Yinjuan Bai
*Department of Chemistry, Northwest University, Shaanxi Province Key Laboratory of Physico-inorganic Chemistry. Xi’an, Shaanxi 710069, P. R. China, Email: lujunyuehotmail.com
J. Lu, Y. Bai, Synthesis, 2002, 466-470.
An efficient synthesis of 3,4-dihydropyrimidinones from the aldehyde, β-keto ester and urea in ethanol, using ferric chloride hexahydrate or nickel chloride hexahydrate as the catalyst, is described. Compared with the classical Biginelli reaction conditions, this new method offers better yields and shorter reaction time.
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Biginelli reaction, dihydropyrimidine-2(1H)-ones, nickel chloride hexahydrate, ferric chloride hexahydrate