A Highly Efficient Three-Component Coupling of Aldehyde, Alkyne, and Amines via C-H Activation Catalyzed by Gold in Water
Chunmei Wei and Chao-Jun Li*
*Department of Chemistry, McGill University, 801 Sherbrooke St. West,
Montreal, QC H3A 2K6 Canada, Email: cj.li
mcgill.ca
C. Wei, C.-J. Li, J. Am. Chem. Soc., 2003, 125, 9584-9585.
DOI: 10.1021/ja0359299
Abstract
A highly efficient gold-catalyzed three-component-coupling of aldehydes, alkynes, and amines in water was developed. Excellent yields of the corresponding propargylamines were obtained in most cases for both aromatic and aliphatic aldehydes and various amines.
see article for more examples
The First Silver-Catalyzed Three-Component Coupling of Aldehyde, Alkyne, and Amine
C. Wei, Z. Li, C.-J. Li, Org. Lett., 2003, 5, 4473-4475.
Key Words
propargylamines, multicomponent reactions, green chemistry
ID: J48-Y2003-1550
