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Water Enables Direct Use of Allyl Alcohol for Tsuji-Trost Reaction without Activators

Hidenori Kinoshita, Hiroshi Shinokubo and Koichiro Oshima*

*Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan, Email: oshimaorgrxn.mbox.media.kyoto-u.ac.jp

H. Kinoshita, H. Shinokubo, K. Oshima, Org. Lett., 2004, 6, 4085-4088.

DOI: 10.1021/ol048207a (free Supporting Information)


Abstract

An aqueous biphasic reaction system enables the direct use of allyl alcohol in the Tsuji-Trost reaction without the help of any activating reagents. The neutral to basic reaction conditions allow the use of amines as nucleophiles.

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Key Words

Trost Allylation, Allylation, Allylamines, Active Methylenes


ID: J54-Y2004-1340