A New Copper Acetate-Bis(oxazoline)-Catalyzed, Enantioselective Henry Reaction
David A. Evans,* Daniel Seidel, Magnus Rueping, Hon Wai Lam, Jared T. Shaw and C. Wade Downey
*Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, Email: evanschemistry.harvard.edu
D. A. Evans, D. Seidel, M. Rueping, H. W. Lam, J. T. Shaw, C. W. Downey, J. Am. Chem. Soc., 2003, 125, 12692-12693.
DOI: 10.1021/ja0373871 (free Supporting Information)
A highly enantioselective, nitroaldol reaction of both aromatic and aliphatic aldehydes catalyzed by a chiral Cu(II) bis(oxazoline) complex afforded products in good yields and enantioselectivities. The sense of asymmetric induction is discussed.
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