A High-Yielding General Synthesis of α-Lactams
Victor Cesare*, Theresa M. Lyons, István Lengyel
*Department of Chemistry, St. John"s University, Jamaica, New York 11439,
U.S.A., Email: cesarev
stjohns.edu
V. Cesare, T. M. Lyons, I. Lengyel, Synthesis, 2002, 1716-1720.
DOI: 10.1055/s-2002-33652
Abstract
A high-yielding general synthesis of α-lactams (aziridinones) is described. An α-haloamide precursor is cyclized by sodium hydride in the presence of 15-crown-5 ether at room temperature, using dichloromethane as the solvent. The by-products, hydrogen gas and sodium halide, are easily removed.
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Key Words
aziridinones, dehydrohalogenation, heterocycles, ring closure
ID: J66-Y2002-1620
