Organic Chemistry Portal

Abstracts

Search:

The First Applications of Carbene Ligands in Cross-Couplings of Alkyl Electrophiles: Sonogashira Reactions of Unactivated Alkyl Bromides and Iodides

Matthias Eckhardt and Gregory C. Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: gcfmit.edu

M. Eckhardt, G. C. Fu, J. Am. Chem. Soc., 2003, 125, 13642-13643.

DOI: 10.1021/ja038177r



see article for more reactions

Abstract

A Pd/N-heterocyclic carbene-based catalyst achieves the Sonogashira coupling of an array of functionalized, β-hydrogen-containing alkyl bromides and iodides under mild conditions.

see article for more examples



Key Words

Sonogashira Coupling, Alkynes


ID: J48-Y2003-1670