Direct α-Fluorination of Ketones Using N-F Reagents
Stojan Stavber*, Marjan Jereb, Marko Zupan
*Laboratory for Organic and Bioorganic Chemistry, ‘Jozef Stefan’ Institute
and Department of Chemistry, University of Ljubljana, Jamova 39, 1000 Ljubljana,
Slovenia,
Email: stojan.stavber
ijs.si
S. Stavber, M. Jereb, M. Zupan, Synthesis, 2002, 2609-2615.
DOI: 10.1055/s-2002-35625
Abstract
The use of 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Accufluor NFTh) as a fluorine transfer reagent and methanol as solvent enabled direct regiospecific fluorofunctionalization of the α-carbonyl position in ketones without prior activation of the target molecules.
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Key Words
fluorination, ketones, Accufluor, NFTh, keto steroids
ID: J66-Y2002-1700
