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Iron-Catalyzed Cross-Coupling of Primary and Secondary Alkyl Halides with Aryl Grignard Reagents

Masaharu Nakamura,* Keiko Matsuo, Shingo Ito, and Eiichi Nakamura*

*Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email: masaharuchem.s.u-tokyo.ac.jp, nakamurachem.s.u-tokyo.ac.jp

M. Nakamura, K. Matsuo, S. Ito, E. Nakamura, J. Am. Chem. Soc., 2004, 126, 3686-3687.

DOI: 10.1021/ja049744t (free Supporting Information)


Abstract

An iron-catalyzed cross-coupling reaction of a primary or secondary alkyl halide with an aryl Grignard reagent proceeds under mild conditions to give the corresponding coupled product in excellent yield.


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Key Words

Cross-Coupling


ID: J48-Y2004-1410