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P-Chirogenic Diaminophosphine Oxide: A New Class of Chiral Phosphorus Ligands for Asymmetric Catalysis

Tetsuhiro Nemoto, Takayoshi Matsumoto, Takamasa Masuda, Tsukasa Hitomi, Keiichiro Hatano and Yasumasa Hamada*

*Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, Email: hamadap.chiba-u.ac.jp

T. Nemoto, T. Matsumoto, T. Masuda, T. Hitomi, K. Hatano, Y. Hamada, J. Am. Chem. Soc., 2004, 126, 3690-3691.

DOI: 10.1021/ja031792a (free Supporting Information)


Abstract

A novel P-chirogenic diaminophosphine oxide was applied to catalytic enantioselective construction of quaternary carbon centers using Pd-catalyzed asymmetric allylic substitution with various β-keto esters.

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Key Words

Tsuji-Trost Reaction


ID: J48-Y2004-1420