Direct and Enantioselective Organocatalytic α-Chlorination of Aldehydes

Michael P. Brochu, Sean P. Brown and David W. C. MacMillan*

*Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, Email: dmacmillcaltech.edu

M. P. Brochu, S. P. Brown, D. W. C. MacMillan, J. Am. Chem. Soc., 2004, 126, 4108-4109.

DOI: 10.1021/ja049562z

---

Abstract

The use of enamine catalysis has provided a new organocatalytic strategy for the enantioselective chlorination of aldehydes to generate α-chloro aldehydes, an important chiral synthon for chemical and medicinal agent synthesis.

see article for more examples

---

---

Key Words

α-Chlorination, Organocatalysis

---

ID: J48-Y2004-1470