Rapid, Efficient and Chemoselective Deoxygenation of Sulfoxides to Thioethers Using NaBH4/I2
Babak Karimi*, Daryoush Zareyee
*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), P. O. Box 45195-159, Gava Zang, Zanjan, Iran, Email: karimiiasbs.ac.ir
B. Karimi, D. Zareyee, Synthesis, 2003, 335-336.
Sodium borohydride in the presence of iodine in anhydrous THF converts various sulfoxides to their thioethers in excellent yields. A chemoselective deoxygenation of sulfoxides can be achieved in the presence of other reducible functional groups such as esters, nitriles and double bonds.
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B. Karimi, D. Zareyee, Synthesis, 2003, 1875-1877.