Synthesis of N-Benzhydrylamides from Nitriles by Ritter Reactions in Formic Acid
Glen C. Gullickson, David E. Lewis*
*Department of Chemistry, University of Wisconsin - Eau Claire, Eau Claire WI 54702-4004, USA, Email: lewisduwec.edu
G. C. Gullickson, D. E. Lewis, Synthesis, 2003, 681-684.
Benzhydrol reacts with nitriles in refluxing formic acid to produce amides arising from the Ritter reaction. The mild conditions permit the preparation of acrylamides and methacrylamides without polymerization of the nitrile.
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