Nickel-Catalyzed Cross-Couplings of Organosilicon Reagents with Unactivated Secondary Alkyl Bromides

David A. Powell and Gregory C. Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: gcfmit.edu

D. A. Powell, G. C. Fu, J. Am. Chem. Soc., 2004, 126, 7788-7789.

DOI: 10.1021/ja047433c

---

Abstract

A nickel-catalyzed cross-coupling of organosilicon compounds with alkyl halides offers a broad substrate scope (secondary electrophiles and functional-group compatibility) and a remarkable air stability of the catalyst components.

see article for more examples

---

---

Room-Temperature Hiyama Cross-Couplings of Arylsilanes with Alkyl Bromides and Iodides

J.-Y. Lee, G. C. Fu, J. Am. Chem. Soc., 2003, 125, 5616-5617.

Amino Alcohols as Ligands for Nickel-Catalyzed Suzuki Reactions of Unactivated Alkyl Halides, Including Secondary Alkyl Chlorides, with Arylboronic Acids

F. González-Bobes, G. C. Fu, J. Am. Chem. Soc., 2006, 128, 5360-5361.

---

Key Words

Hiyama Coupling, Silanes, Arenes

---

ID: J48-Y2004-1530