Effective Fluorination Reaction with Et₃N • 3 HF Under Microwave Irradiation

Tomotake Inagaki, Tsuyoshi Fukuhara, Shoji Hara*

*Division of Molecular Chemistry, GraduateSchool of Engineering, Hokkaido University, Sapporo 060-8628, Japan, Email: haraorg-mc.eng.hokudai.ac.jp

T. Inagaki, T. Fukuhara, S. Hara, Synthesis, 2003, 1157-1159.

DOI: 10.1055/s-2003-39162

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Abstract

Fluorinations of epoxides and alkyl mesylates can be effectively achieved by reaction with Et₃N • 3 HF under microwave irradiation. The reactions were completed in a few minutes and the use of large excess of reagents could be avoided.

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Key Words

microwave synthesis, epoxides, fluorohydrins, fluoroalkanes, ring opening, Et₃N • 3 HF

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ID: J66-Y2003-1850