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Synthesis of Substituted Indoles and Carbazoles from 2-Fluorophenyl Imines

Linas V. Kudzma*

*Baxter Healthcare Corporation, Anesthesia and Critical Care, 95 Spring Street, New Providence, NJ 07974, USA, Email: linas_kudzmabaxter.com

L. V. Kudzma, Synthesis, 2003, 1661-1666.

DOI: 10.1055/s-2003-40880


Abstract

The synthesis of a series of indole and carbazole derivatives from 2-fluorophenyl imines is reported. 2-Fluoroaniline-d4 is prepared and used to investigate the mechanism of this indolization.

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Key Words

indoles, imines, enaminone, benzyne, nucleophilic aromatic substitution


ID: J66-Y2003-1900